What triggers the breakdown of hydrostatic equilibrium leading a star to evolve off the main sequence?

Answer

The fusion rate drops when the core hydrogen fuel is exhausted

When the core hydrogen fuel runs out, the fusion rate slows significantly, causing the outward pressure to drop, allowing gravity to gain the upper hand and initiate collapse.

What triggers the breakdown of hydrostatic equilibrium leading a star to evolve off the main sequence?
stabilitygravitystarastrophysicspressure