What unique, often insurmountable drawback do space-based telescopes face compared to ground-based equipment?

Answer

Difficulty or impossibility of servicing and repair

If a critical component on an orbital telescope fails due to radiation or impacts, repairing or servicing it is immensely complicated, prohibitively expensive, or physically impossible if the design did not account for maintenance.

What unique, often insurmountable drawback do space-based telescopes face compared to ground-based equipment?

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