What event signals the definitive end of a star's main-sequence life?

Answer

Exhaustion of hydrogen fuel in the core

The star's stability is anchored to the steady fusion of hydrogen into helium; when this fuel is spent, the primary source of outward pressure vanishes, marking the end of the main-sequence life.

What event signals the definitive end of a star's main-sequence life?
physicsscienceinstabilitystellarstar