Which intermediate species are considered the most damaging agents in many proteinopathies, preceding large fibril formation?

Answer

Soluble oligomers

The most damaging agents are generally identified as soluble oligomers, which are small clusters of misfolded proteins that form before the development of large, insoluble amyloid fibrils.

Which intermediate species are considered the most damaging agents in many proteinopathies, preceding large fibril formation?
structurediseaseproteincausemisfolding