What consequence occurs when large amyloid deposits physically clog the cell's primary protein disposal system?

Answer

The disposal system becomes less effective

The physical accumulation of large amyloid deposits can clog the machinery of the proteasome, creating a feedback loop that reduces the efficiency of the cell's primary protein disposal mechanism precisely when it is most needed.

What consequence occurs when large amyloid deposits physically clog the cell's primary protein disposal system?
structurediseaseproteincausemisfolding