Which condition is listed as a key internal stressor activating the intrinsic apoptotic pathway?
Answer
Endoplasmic Reticulum (ER) stress.
Internal stresses that activate the intrinsic pathway include irreparable DNA damage, oxidative stress, growth factor withdrawal, and the accumulation of unfolded or misfolded proteins within the ER.
Related Questions
What critical feature distinguishes apoptosis from necrosis?What molecules initiate the extrinsic pathway of apoptosis?What event signals the point of no return in the intrinsic (mitochondrial) pathway?Which large structure is formed when released Cytochrome c binds to Apaf-1 and dATP?What complex is assembled upon ligand binding in the extrinsic pathway?How do executioner caspases directly cause DNA fragmentation during apoptosis?Which members of the Bcl-2 family function as pro-apoptotic effectors forming pores in the mitochondrial membrane?Which condition is listed as a key internal stressor activating the intrinsic apoptotic pathway?How does the extrinsic pathway amplify its signal through the intrinsic pathway?What consequence is associated with the inappropriate dominance of anti-apoptotic signals like Bcl-2 overexpression?