How does the extrinsic pathway amplify its signal through the intrinsic pathway?
Answer
Activated caspase-8 cleaves Bid (generating tBid) which promotes Cytochrome c release.
In many cell types, activated caspase-8 from the extrinsic pathway cleaves the pro-survival protein Bid into truncated Bid (tBid), which then translocates to the mitochondria to trigger the release of Cytochrome c, thereby engaging the intrinsic machinery.
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