What signaling pathway do Bone Morphogenetic Proteins (BMPs) synergize with by suppressing an opposing pathway in mouse ESC maintenance?
Answer
The MAPK/ERK pathway
In maintaining mESCs, BMPs suppress the differentiation-driving MAPK/ERK pathway, often working alongside LIF signaling through JAK/STAT3.
Frequently Asked Questions
Which three transcription factors constitute the core regulatory circuit maintaining PSC undifferentiated status?What role does c-Myc primarily serve during the *maintenance* phase of pluripotency?What signaling pathway do Bone Morphogenetic Proteins (BMPs) synergize with by suppressing an opposing pathway in mouse ESC maintenance?Which growth factor combination is required for the self-renewal of human Embryonic Stem Cells (hESCs) in standard conditions?What characteristic is associated with promoters that are highly likely to be actively transcribed in the pluripotent state?What specific inhibitors are used to push mESCs into the 'naive ground state', making them independent of LIF/STAT3?What epigenetic structure, featuring both active and repressive marks, keeps developmental genes poised for activation in PSCs?Which complex is responsible for establishing the repressive mark H3K27me3 in embryonic stem cells?How does the primary ATP generation method in PSCs compare to that of somatic cells?What characteristic describes the overall chromatin structure in PSCs related to histone turnover?What major epigenetic hallmark of commitment is present in primed hESCs but absent in naive mESCs?