What primarily differentiates the transition from protective acute inflammation to harmful chronic inflammation?

Answer

How long the signals stay active and where they are signaling

The shift to a chronic state is less dependent on the identity of the chemicals involved and more dependent on the duration of their activity and the location of their signaling.

What primarily differentiates the transition from protective acute inflammation to harmful chronic inflammation?

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Inflammation: Immune Response to Tissue Injury or Infection

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