Which brain regions are primarily implicated in processing the affective (unpleasantness) and cognitive-evaluative dimensions of pain experience?
Answer
Anterior Cingulate Cortex (ACC) and Insular Cortex (IC)
The Anterior Cingulate Cortex and the Insular Cortex are specialized brain areas associated with chronic pain remodeling that process the emotional impact and cognitive assessment of the pain signal, distinguishing the network from that of acute pain.
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