What system's chronic dysregulation, often due to stress or trauma, can lead to peripheral sensitization by activating immune cells near sensory nerve endings?
Answer
Hypothalamic-Pituitary-Adrenal (HPA) axis
Chronic alteration of the HPA axis results in abnormal stress responses. Mediators like Corticotropin-releasing factor (CRF) released during stress activation can act on Mast Cells (MCs), causing them to release mediators that sensitize nearby nociceptors.
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