What mechanism involves a regulator binding to a site *separate* from the active site to modulate function?

Answer

Allosteric Regulation.

Allosteric regulation involves a regulatory molecule binding to a distinct allosteric site, triggering a global conformational change in the protein, which in turn alters the shape and binding affinity of the distant active site.

What mechanism involves a regulator binding to a site *separate* from the active site to modulate function?
controlreactionenzymecatalystspecificity