How is the three-dimensional structure of the active site formed?

Answer

By amino acid residues drawn together from various parts of the folded polypeptide chain.

The active site is a specialized cleft created by the precise three-dimensional folding of the enzyme, bringing specific amino acid side chains from distant locations along the polypeptide chain into proximity to engineer a unique chemical microenvironment.

How is the three-dimensional structure of the active site formed?
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